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Benefits of Fluorous Chemistry
Fluorous chemistry is based on the presence of fluorinated domains (significant numbers of fluorinated carbon atoms adjacent to one another) within chemical compounds. Such compounds (reagents, sorbents etc..) are said to be "fluorous" in nature and have unique and useful properties, due to a highly selective "fluorous interactions". Fluorous technology offers two significant benefits to high-throughput synthesis and purification:
- It offers the ability to purify all fluorous-containing products from non-fluorous starting materials using identical chromatographic procedures.
- It allows for "single pot" reactions, where multiple substrates containing different fluorous chain lengths can be transformed in a single reaction mixture, then separated ("de-mixed") from one another via a fluorous column.
The web site "Fluorous Chemistry" is an excellent starting point for both a researcher new to the field as an expert who is looking for a intuitively organized web site about this subject.
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