Solid Phase Extraction

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Benefits of Solid Phase Extraction
Solid Phase Extraction (SPE) is widely used for the purification of small compound libraries synthezised in solution. Compared to the classic liquid-liquid extraction using the separatory funnel or the preparative HPLC purification it offers several advantages:

  • Reduced lab time
  • Easy manipulation
  • Lesser amount of solvent required, no disposal of large quantaties of organic solvents
  • Higher concentration factor
  • No problem with the miscibility of solvent
  • Easy adaptable for very selective extraction
  • Easy automatisation
  • Avoids problems such as incomplete phase separations, less-than-quantitative recoveries and emulsion formation as encountered in liquid-liquid extractions

Reaction mixtures from parallel synthesis can easily be purified in a parallel fashion with commercially available disposable cartridges/tubes/disks and a vacuum manifold. However, a basic knowledge is necessary of how to perform SPE extractions in a efficient way by selecting the right sorbent (from a variety of reversed, normal or ion exchange phases), conditioning, selective washing and eluting the compounds of interest.

Directory Contents
The web site "Solid Phase Extraction in Organic Synthesis" is an excellent starting point for both a researcher new to the field as an expert who is looking for a intuitively organized web site about this subject.


  • Introduction (6 listings)
  • Sorbent Suppliers (10 listings)
  • Vacuum Manifolds (5 listings)
  • Automated Systems (14 listings)
  • Recent Reviews (5 listings)
  • Recent Books (4 listings)