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REACTION DATABASES

Allow searching on reactions to obtain reaction and/or bibliographic data

Free
  • Chemogenesis

    Chemogenesis is a free web book, dealing with chemical reactions and chemical reactivity. It examines the rich science between the periodic table and the established disciplines of inorganic and organic chemistry.

  • LigBank

    A database of ligands for catalytic reactions in synthetic organic chemistry. The objective is to promote exchange of new ligands and to facilitate their commercialisation.

  • Organic Syntheses

    Database with 2400 articles and over 6000 independently tested and proven reactions. If carefully followed, it permits the advanced research student or professional chemist skilled in the field to prepare compounds of research utility.

  • Reaction Database - Chemical Synthesis

    This online tool enables you to find detailed literature procedures for a desired transformation by entering the starting material and product-of-interest. In addition, the procedures include a list of reagents needed as well as links to their respective product detail pages.

  • SyntheticPages

    SyntheticPages is a freely available interactive database of synthetic chemistry. Practical and reliable organic, organometallic and inorganic chemical synthesis, reactions and procedures are published.

  • Synthesis Protocols

    A database for solid phase, solution phase and library synthesis procedures currently developed at Boston University's Center for Chemical Methodology and Library Development.

  • The Chemical Thesaurus

    The Chemical Thesaurus is a reaction chemistry information system which removes the artificial barriers between different subdisciplinary areas of chemistry by presenting a unified vision of inorganic and organic reaction chemistry.

    • Coverage: over 3,500 individual reactions, 3,700 species and 20,000 relational links
    • Guides: overview
    • Access: free, open access resource, online and downloadable non-web version

  • Webreactions

    Reaction search system based on reaction types and bonding change, rather than on a search for structures of substrates and products.

    • Coverage: about 400,000 individual reactions (1975 - 1991)
    • Guides: Reaction Searching with WebReactions
    • Access: only working in a Netscape Navigator/Windows environment

Commercial
  • Beilstein

  • CASREACT

    • Focus: comprehensive coverage of organic chemistry literature
    • Coverage: > 11 million single- and multi-step reactions (journals: 1974-, patents: 1985- ) [latest count]
    • Source: journals and patents indexed in the Organic Sections of CA
    • Guides:
    • Access: Scifinder, Scifinder Scholar, STN on the web and STN.

  • ChemInform Reaction Library

    • Focus: New reactions and syntheses, including enzymatic and microbial processes; applications of known methods in new areas; heterocyclic chemistry, natural product, and organo-element synthesis; new catalysts
    • Coverage: > 900,000 reactions and > 1,000,000 molecules (1900 - )
    • Access: MDL Reaction Browser (in-house system) or online via DiscoveryGate

  • ChemPrep Reaction

    • Focus: General organic synthesis
    • Coverage: > 400,000 reactions (1986-, updated by 35,000 reactions/year)
    • Access: CD-Rom

  • Current Chemical Reactions

    • Focus: Latest synthetic methods. Access to comprehensive reaction information, including detailed experimental conditions, full reaction flows, product yields, and key step indicators
    • Coverage: > 400,000 reactions

  • Current Synthetic Methodology

    • Focus: New reagents or important modifications of known reagents, Chemo-, regio-, and stereoselective reactions and new synthetic methodology
    • Coverage: 75,000 reactions and 122,000 molecules (1992-)

  • Derwent Journal of Synthetic Methods

    • Focus: novel reactions or reactions with significant advantages over previous reports
    • Coverage: > 73,000 reactions and > 116,000 molecules (1980- )
    • Source: 130 primary chemical journals and patents from 40 issuing authorities

  • Encyclopedia of Reagents for Organic Synthesis (e-EROS)

    • Focus: systematic and exhaustive coverage of reagents used in organic chemistry
    • Coverage: 3,600 reagents and around 50,000 reactions.

  • Failed Reactions

    • Focus: reactions with unexpected results

  • ORGSYN

    • Focus: An electronic version of the entire series of Organic Syntheses (first published in 1921), the ORGSYN Database offers proven high-yield synthetic methods and preparations of specific compounds of broad interest to synthetic chemists.
    • Coverage: 5,500 reactions and 5,900 molecules (1921-)
    • Source: Organic Syntheses

  • Journal of Synthetic Methods

    • Focus: detailed information about new synthetic methods, high-yield functional group transformations, improvements to existing methodologies, and reactions representing the most significant new patents.
    • Coverage: 73,300 reactions and 116,200 molecules (1980- )
    • Source: Derwent's Journal of Synthetic Methods

  • Protecting groups (SPG)

    • Focus: Methods for protection, deprotection and transprotection and includes the ability to search generically, based on functional groups, protected groups, tolerated groups and reaction conditions.

  • Reaction Citation Index

    • Focus: combination of Current Chemical Reactions and Science Citation Index
    • Coverage: > 500,000 reactions and > 2 million references (1980 -)
    • Source: organic chemistry journals
    • Access: magnetic tape

  • Reference Library of Synthetic Methodology

    • Focus: novel organic synthetic methodologies, selective functional group transformations, metal-mediated chemistry, and asymmetric syntheses
    • Coverage: 209,800 reactions and 271,000 molecules (1946-1991)
    • Source: Combination of THEILHEIMER (Synthetic Methods of Organic Chemistry 1946-1980); Current Literature File (primary literature 1983-1991; Core (primary literature through 1991); CHIRAS (asymmetric synthesis literature 1975-1991); and METALYSIS (metal-mediated transformation literature 1974-1991)

  • Science of Synthesis (electronic version)

    • Focus: critical treatment of synthetic organic and organometallic chemistry (previously Houben-Weyl). Contains evaluated methodology, detailed experimental procedures, and a discussion of the field.
    • Coverage: about 180,000 reactions and 800,000 structures
    • Source: journal and patent literature (1800-present)
    • Access: internet/intranet

  • Solid Phase Organic Reactions

    • Focus: solid-phase organic chemistry (polymeric materials, linkers, solid supports and protecting groups)
    • Coverage: 17,500 reactions and 25,900 molecules (1963- )

  • Solid-Phase Synthesis (SPS)

    • Focus: solid-phase organic chemistry

  • SPRESIweb

    • Focus: organic reactions
    • Coverage: 3.7 million reactions
    • Access: Internet(intranet) or SD file

  • Synthline® on the Web

    • Focus: presents in structure-searchable format the schemes of synthesis for drugs currently on the market or in development worldwide
    • Coverage: 15,146 synthesis schemes, 9,504 end products, 68,077 synthesis intermediates, 2,784 chemical reagents, 1,870 intermediate & reagent suppliers, 11,047 references and 8,075 patent families
    • Source: Publications in the field of medicinal chemistry and the current patent literature. The database includes all schemes of synthesis published in the Prous Science journal Drugs of the Future since January 1976.
    • Access: Internet or CD-rom